Publications by authors named "I D Chkhikvishvili"
Background: Hereditary cancer is estimated to account for up to 10% of the worldwide cancer burden; 5% of all thyroid cancers are thought to be genetic. Inheritance of a deleterious mutation in genes associated with a high lifetime risk of developing cancer. Cancer-predisposing genes can promote the initiation and progression of thyroid cancer by enhancing the activation of major signaling pathways through oxidative stress mechanisms.
View Article and Find Full Text PDFAim: The purpose of the study was to compare the morbidity from cancer (expressed as incidence) to the average levels of blood serum inflammatory markers in the population of the Sachkhere region (Georgia).
Methods: healthy residents of the Sachkhere district were examined. In the blood serum samples of patients, the cytokines (IL-1α, IL-10, TGF-β, IL-12, IL-17, TNF-α, IL-6) and NOx content, as well as the total antioxidant activity of the non-enzymatic system (TAA) were determined; using light microscopy, buccal micronuclei (MnB) of epithelial cells of the oral mucosa, as indicators of chromosomal disorders, were studied.
Spatial-temporal monitoring of the health status of the population plays an important role in public health. For identifying and considering the effects of heterogeneity at the subpopulation level, Bayesian methods for analyzing mixtures of the probability distributions are currently being intensively developed. This article presents the results of studies of the distribution spectrum of the blood total antiradical activity (TAA) levels of the Sachkhere district (Georgia) villages' (Chorvila, Sareki, Sairkhe) population.
View Article and Find Full Text PDFThe aim of our study is to evaluate the mechanisms of anti-inflammatory property of Tagetes patula L. (French Marigold) flower extracts and its protective effect on renal epithelium against uropathogenic E. coli infection.
View Article and Find Full Text PDFArticle Synopsis
- The study explored the use of liposomes (DPPA and DPPC) to enhance the effectiveness of antioxidant compounds like vitamin C (hydrophilic) and vitamin E (lipophilic) in normal MDCK and tumor Jurkat T cells.
- The effectiveness of vitamins C, E, and their combination with these liposomes was found to be influenced by how well the liposomes integrate with the cell membranes and release the vitamins.
- The findings suggest that these liposomes could selectively regulate antioxidant activity, which is significant for developing targeted antitumor therapies and protective agents for healthy tissues during radiotherapy.