Publications by authors named "I Cooper"
Article Synopsis
- Glioblastoma (GBM) is the deadliest brain tumor in adults, and current therapies are largely ineffective, which drives the need for new treatment strategies based on the tumor's metabolic needs, specifically glucose and glutamine.
- A ketogenic metabolic therapy (KMT) approach targets these metabolic pathways by combining dietary changes with specific drugs to limit glycolysis and glutaminolysis, while promoting the use of non-fermentable fuels like ketones and fatty acids.
- The glucose-ketone index (GKI) serves as a biomarker to monitor treatment effectiveness, aiming to create a more hostile environment for tumor growth and improve outcomes in GBM as well as potentially other cancer types reliant on similar metabolic pathways.
Background: Ketamine is known for its rapid antidepressant effect, but its impact on affective information processing (including attentional bias, a putative cognitive mechanism of depression), remains largely unexplored. We leveraged a novel measurement of attentional bias and sought to: (1) establish adequate test-retest reliability and validity among depressed participants prior to ketamine treatment; and (2) harness a single dose of ketamine to assess mechanistic shifts in attentional bias and their relation to antidepressant efficacy.
Methods: A novel dual probe video task was used to index attentional bias toward sad film clips.
Background: Impairment of balance and gait is common in Multiple Sclerosis (MS). Non-invasive Brain Stimulation techniques are promising adjuncts to physical therapy to improve disability.
Objective: To determine if combining transcranial direct current stimulation (tDCS) with conventional exercise therapy enhances balance and mobility in people with multiple sclerosis (PwMS) compared to exercise alone.
Article Synopsis
- - The systematic review highlights that mind-body, cognitive-behavioral, and physical activity interventions can potentially benefit brain tumor patients, but these strategies are not widely used in neuro-oncology.
- - Out of 29 studies reviewed, mind-body and physical activities showed promising results in improving mood, quality of life, and physical functioning, while cognitive-behavioral interventions had mixed results due to insufficient study power.
- - The review calls for more robust clinical trials to better confirm the effectiveness of these interventions for both physical and psychological health in brain tumor patients.
Article Synopsis
- The study examines bacterial communities and their role in the corrosion of intertidal structures across three UK coastal sites.
- Chemical analyses reveal sulfate-reducing microbes (SRBs) are active at Shoreham and Newhaven but absent at Southend-on-Sea, where corrosion mechanisms differ.
- The research developed a rapid identification method for SRBs using advanced genetic analysis, aiding in understanding and diagnosing different types of intertidal corrosion.