Publications by authors named "I Clark"
Nitroaromatic compounds are found in brown carbon aerosols emitted to the Earth's atmosphere by biomass burning, and are important organic chromophores for the absorption of solar radiation. Here, transient absorption spectroscopy spanning 100 fs-8 μs is used to explore the pH-dependent photochemical pathways for aqueous solutions of -nitrophenol, chosen as a representative nitroaromatic compound. Broadband ultrafast UV-visible and infrared probes are used to characterize the excited states and intermediate species involved in the multistep photochemistry, and to determine their lifetimes under different pH conditions.
View Article and Find Full Text PDFChanges in chondrocyte gene expression can contribute to the development of osteoarthritis (OA), and so recognition of the regulative processes during chondrogenesis can lead to a better understanding of OA. microRNAs (miRNAs) are key regulators of gene expression in chondrocytes/OA, and we have used a combined experimental, bioinformatic, and systems biology approach to explore the multiple miRNA-mRNA interactions that regulate chondrogenesis. A longitudinal chondrogenesis bioinformatic analysis identified paralogues miR-199a-5p and miR-199b-5p as pro-chondrogenic regulators.
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- The study examines the impact of illicit substance use during pregnancy, noting a 4-fold increase over two decades and its negative effects on mothers and fetuses.
- A multicenter retrospective analysis from 2016 to 2021 included 852 pregnant trauma patients (PTPs), with 9.8% testing positive for substances, primarily THC and methamphetamine.
- Findings showed that PTPs with positive urine toxicology had higher rates of blunt head injuries, extremity injuries, domestic violence incidents, and uterine contractions, but similar maternal complication rates compared to those who tested negative.
Article Synopsis
- * In studies with miR-324-null mice, researchers found that these mice had increased bone density and thickness, reduced lipid content in bone marrow, and higher bone formation rates, indicating a strong connection between miR-324 and bone maintenance.
- * It was revealed that miR-324-5p targets key regulators in bone cells, such as Pin1 and Runx2, which influence the balance between bone formation and resorption, highlighting the potential for miR-324-related therapies in treating bone diseases.
Article Synopsis
- A study was conducted to assess the effects of personalized music listening as an addition to standard pulmonary rehabilitation for adults with COPD.
- Participants were randomly divided into a music intervention group, who created playlists with a therapist, and a control group that received standard care during the rehabilitation program.
- Results showed no significant differences in symptoms of breathlessness and exertion between the two groups, although both groups experienced improvements, suggesting that the added benefit of music therapy remains unclear due to study limitations related to COVID-19.