Publications by authors named "I Chun Chou"
Article Synopsis
- Plaque radiotherapy is a targeted treatment for medium-sized ocular tumors like uveal melanoma, using customized plaques to deliver precise radiation while minimizing damage to surrounding healthy tissue.
- The choice of radioisotope, such as Ruthenium-106 or Iodine-125, is based on factors like tumor characteristics and desired treatment duration, with high dose rate (HDR) options facilitating quicker treatment.
- Efficacy of Ruthenium-106 varies significantly, and outcomes can be influenced by tumor size, thickness, and location; however, plaque brachytherapy can offer similar survival rates to more invasive treatments like enucleation for suitable cases.
Article Synopsis
- Redox imbalance and oxidative stress are linked to serious health issues like neurodegenerative disorders, cancer, and premature aging, making accurate detection of antioxidants important for managing these conditions.
- This study introduces a new fluorescence-based assay that uses dithiothreitol (DTT)-assisted gold nanoclusters (DTT@BSA-AuNCs) to detect antioxidant levels more effectively than traditional methods, which often miss thiol-containing antioxidants.
- The assay can identify antioxidants like ascorbic acid and glutathione at very low concentrations and has proven effective in human saliva and cancer cell models, offering a reliable and cost-effective way to monitor oxidative stress in various diseases.
Background: Post-acute sequelae of SARS-CoV-2 infection (PASC) affects patients after recovering from acute coronavirus disease 2019 (COVID-19). This study investigates the impact of SARS-CoV-2 vaccination on PASC symptoms in children in Taiwan during the Omicron pandemic.
Methods: We enrolled children under 18 years with PASC symptoms persisting for more than 4 weeks.
Article Synopsis
- Protocadherin-19 (PCDH19) epilepsy is a rare condition primarily affecting females, characterized by early-onset seizures and developmental delays due to mutations in the PCDH19 gene on the X chromosome.
- A study of fifteen female patients in Taiwan revealed that seizures typically began between 4 months and 2 years of age, often occurring in clusters, with varying levels of intellectual disability among the patients.
- The research identified distinct mutations in the PCDH19 gene and highlighted the use of multiple antiseizure medications, with some patients achieving seizure freedom, but no specific medication class proven most effective for this syndrome.
Background: More than 50% of esophageal cancer patients are diagnosed with advanced diseases and commonly experience dysphagia, some of whom even have tracheoesophageal fistula. Self-expandable metal stent (SEMS) is one of the recommended palliative methods, although complications such as chest pain and stent migration are not uncommon. The goal of this study was to examine the predictors of stent migration.
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