Publications by authors named "I Chianella"
Lung cancer is the most common type of cancer diagnosed worldwide and is also among the most fatal. Early detection, before symptoms become evident, is fundamental for patients' survival. Therefore, several lung cancer biomarkers have been proposed to enable a prompt diagnosis, including neuron-specific enolase (NSE) and carcinoembryonic antigen (CEA).
View Article and Find Full Text PDFThe presence of organic UV filters (OUVAs) has been detected worldwide in aquatic ecosystems. These pollutants, originating from various anthropogenic sources, can persist and transform within wastewater treatment plants (WWTPs), posing a potential environmental hazard. In this framework, this research presents electrochemical sensors based on molecularly imprinted polymers (MIPs) for the selective detection of Benzophenone-3 (BP-3) and Octocrylene (OC), two of the OUVA most spread in the aquatic environment, to overcome the analytical challenges related to the quantification of this class of contaminants in wastewater samples.
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- Molecularly imprinted polymers (MIPs) are custom-made synthetic receptors designed for selective and robust sensing of target analytes, but their synthesis results in a range of binding site affinities.
- The study compared the performance of two types of electrochemical sensors using MIPs: one with inhomogeneous binding sites ("Imprinted PANI layer") and another with uniform binding sites through the addition of nanoparticles ("nanoMIP-doped PANI").
- Results showed that the nanoMIP-doped PANI sensor had almost double the sensitivity compared to the imprinted PANI layer, indicating that the uniformity of binding sites significantly enhances sensor performance, with effective detection of the hormone 17β-estradiol in wastewater.
Gastrointestinal bleeding (GIB) is a serious medical condition, which requires immediate attention to establish the cause of the bleeding. Here, we present the development of a miniaturised electrochemical impedance spectroscopy (EIS) device for the detection of GIB. The device performs EIS measurements up to 100 kHz.
View Article and Find Full Text PDFThe emergence of multidrug-resistant bacteria has driven the need for novel antibiotics. Our investigations have focussed on lichens as they naturally produce a wide range of unique and very effective defence chemicals. The aim of this study was to evaluate some of the antimicrobial properties of ten common British churchyard lichens.
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