Publications by authors named "I Chavez-Uribe"
Article Synopsis
- The scorpion toxin tamapin is the most effective blocker of KCa2.2 channels, with this study examining its creation, structure, and cancer cell toxicity.
- Researchers tested tamapin and five mutated versions on Jurkat T and breast cancer cells, finding that tamapin and its variants caused cell death in a dose- and time-dependent manner.
- Structural analysis showed that tamapin maintains its shape despite mutations, while changes in toxicity suggest the importance of specific amino acids in interacting with KCa2.2 channels to induce cell death.
The roots of the tropical tree Lonchocarpus oaxacensis afforded the 3-hydroxyflavanones jayacanol and mundulinol, as well as two flavanones, mundulin and minimiflorin. Flavonoids bearing 6,7-(dimethylpyran) and 8-(gammagamma-dimethyl allyl) substituents are characteristic for species grouped in the Minimiflori subsection. Therefore this subsection seems to be chemically and morphologically homogeneous.
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