Publications by authors named "I Ceberio"
The early introduction of a low phenylalanine (Phe) diet has been demonstrated to be the most successful treatment in subjects with phenylketonuria (PKU), especially for preventing severe cognitive and neurological damages. However, it still concerns that even if treated in the first months of life with supplements and following a diet, they can show slight scores below people without PKU in neuropsychological assignments. We investigated 20 adults with classical PKU aged 19-48 years (mean age 29 years) and 20 heathy controls matched by age, gender, and years of education.
View Article and Find Full Text PDFArticle Synopsis
- Follicular lymphoma (FL) is a type of slow-growing B-cell lymphoma that can turn into a more aggressive form known as transformed FL (tFL), but the mechanisms behind this transformation are not well understood.
- Researchers investigated mutations in microRNA (miRNA)-binding sites within the genomes of FL and tFL patients, identifying 544 mutations linked to these regions.
- Out of a targeted sequencing study of 55 FL patients, they found 16 recurrent mutations and 69 additional variants, leading to the identification of 21 mutated genes associated with B-cell functions, with over 40% of these mutations present only in tFL patients.
Large series of patients with acute myelogenous leukemia (AML) after ex vivo T cell-depleted (TCD) allogeneic hematopoietic stem cell transplantation (allo-HSCT) have not been reported previously. We retrospectively analyzed the outcomes of 266 patients (median age, 54 years) with AML who received CD34-selected TCD allo-HSCTs while in first (75%) or second (25%) complete remission (CR1/CR2) at a single institution. The conditioning regimens were all myeloablative, and no additional graft-versus-host disease (GVHD) prophylaxis was given.
View Article and Find Full Text PDFArticle Synopsis
- The study examined how the hematopoietic cell transplantation-comorbidity index (HCT-CI) and its age-adjusted version (HCT-CI/age) relate to transplant outcomes in patients with acute myeloid leukemia and myelodysplastic syndrome undergoing allogeneic HCT with CD34-selected grafts.
- Higher scores on both indices were associated with increased nonrelapse mortality and decreased overall survival, with the HCT-CI defining two distinct risk groups, while the HCT-CI/age showed a progressive risk increase across four categories.
- Both models demonstrated effective predictive accuracy for nonrelapse mortality, suggesting they could help in selecting appropriate patients for allogeneic HCT.
The role of hematopoietic cell transplantation (HCT) in the therapy of Hodgkin lymphoma (HL) in pediatric and adult patients is reviewed and critically evaluated in this systematic evidence-based review. Specific criteria were used for searching the published literature and for grading the quality and strength of the evidence and the strength of the treatment recommendations. Treatment recommendations based on the evidence are included and were reached unanimously by a panel of HL experts.
View Article and Find Full Text PDF