Publications by authors named "I Cassimjee"
Article Synopsis
- The immune system plays a crucial role in cardiovascular health, particularly in relation to inflammation and its impact on heart disease.
- Atherosclerosis is characterized by lipid-driven inflammation, where macrophages are key players; however, recent research indicates that there are different macrophage states associated with lipids and inflammation.
- This study identifies a specific type of macrophage linked to cerebrovascular events and suggests that targeting these inflammatory lipid-associated macrophages could be a new treatment approach for cardiovascular disease.
Protective Role for Smooth Muscle Cell Hepcidin in Abdominal Aortic Aneurysm.
Arterioscler Thromb Vasc Biol
May 2023
Background: Hepcidin is a liver-derived hormone that controls systemic iron homeostasis, by inhibiting the iron exporter ferroportin in the gut and spleen, respective sites of iron absorption and recycling. Hepcidin is also expressed ectopically in the context of cardiovascular disease. However, the precise role of ectopic hepcidin in underlying pathophysiology is unknown.
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- - The text is a correction relating to a previously published article.
- - It specifically addresses issues found in the original article identified by the DOI 10.1038/s44161-023-00295-x.
- - This correction is essential for ensuring the accuracy and integrity of the published research.
Aims: A lower heart rate (HR) increases central blood pressure through enhanced backward wave pressures (Pb). We aimed to determine whether these relationships are modified by increases in aortic stiffness.
Methods: Using non-invasive central pressure, aortic velocity and diameter measurements in the outflow tract (echocardiography), we assessed the impact of aortic stiffness on relationships between HR and arterial wave morphology in 603 community participants < 60 years of age, 221 ≥ 60 years, and in 287 participants with arterial events [stroke and critical limb ischemia (CLI)].