Publications by authors named "I Carmagnola"
Article Synopsis
- Human cardiac fibrotic tissues are stiffer than healthy tissues and can't contract on their own, highlighting the need for scaffolds that mimic their mechanical properties.
- This study developed bioartificial scaffolds made from PCL and gelatin methacryloyl (GelMA) that replicate the stiffness and stretchability of these fibrotic tissues for better integration with cardiac cells.
- Testing showed that scaffolds support human cardiac fibroblast culture, improve cell viability and organization, and facilitate the presence of smooth muscle actin-positive cells when subjected to dynamic conditions.
Article Synopsis
- * The review discusses innovative biomaterials designed with smart coatings that respond to bacterial presence, allowing for on-demand antibacterial action and reducing the reliance on traditional antibiotics.
- * It emphasizes the importance of developing these self-defensive coatings to minimize antibiotic resistance, protect the natural microbiome, and ultimately lower healthcare expenses while exploring future improvements in this field.
In the past years, the use of hydrogels derived from decellularized extracellular matrix (dECM) for regenerative medicine purposes has significantly increased. The intrinsic bioactive and immunomodulatory properties indicate these materials as promising candidates for therapeutical applications. However, to date, limitations such as animal-to-animal variability still hinder the clinical translation.
View Article and Find Full Text PDFSkeletal muscle tissue (SMT) has a highly hierarchical and anisotropic morphology, featuring aligned and parallel structures at multiple levels. Various factors, including trauma and disease conditions, can compromise the functionality of skeletal muscle. The in vitro modeling of SMT represents a useful tool for testing novel drugs and therapies.
View Article and Find Full Text PDFAdverse remodeling post-myocardial infarction is hallmarked by the phenotypic change of cardiac fibroblasts (CFs) into myofibroblasts (MyoFs) and over-deposition of the fibrotic extracellular matrix (ECM) mainly composed by fibronectin and collagens, with the loss of tissue anisotropy and tissue stiffening. Reversing cardiac fibrosis represents a key challenge in cardiac regenerative medicine. Reliable models of human cardiac fibrotic tissue could be useful for preclinical testing of new advanced therapies, addressing the limited predictivity of traditional 2D cell cultures and animal models.
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