Publications by authors named "I Capuano"
Background: The nephrotoxic effects of non-steroidal anti-inflammatory drugs (NSAIDs) are widely acknowledged. In particular, diclofenac is the most commonly prescribed NSAIDs, but no previous findings of electrolyte disturbances were reported following its administration.
Case Report: We presented the case of a man who experienced significant weakness associated with severe deficiencies in potassium, calcium, and magnesium after misusing diclofenac because of severe back pain.
Background: Physical exercise (PE) can regulate inflammation, cardiovascular health, sarcopenia, anaemia, and bone health in the chronic kidney disease (CKD) population. Experimental and clinical studies both help us better understand the mechanisms that underlie the beneficial effects of the exercise, especially in renal anaemia and CKD-mineral bone disorders (CKD-MBDs). Here, we summarize this evidence, exploring the biological pathways involved, locally released substances, and crosstalk between tissues, but also the shortcomings of current knowledge.
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- Alterations in the basilar artery (BA) anatomy may be linked to Fabry disease (FD), but their clinical significance is unclear due to a lack of data on their impact on patient outcomes.
- A study involving brain MRIs of 53 FD subjects assessed the BA diameter and tortuosity index but found no significant correlations with clinical or imaging data.
- The stability of BA metrics over a 2-year follow-up period indicates that these vessel changes do not predict patient clinical status, suggesting a need to reevaluate their role in the context of FD.
Orexin-A is a neuropeptide product of the lateral hypothalamus that acts on two receptors, OX1R and OX2R. The orexinergic system is involved in feeding, sleep, and pressure regulation. Recently, orexin-A levels have been found to be negatively correlated with renal function.
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