Publications by authors named "I CHOWERS"
Cataract surgery, a common procedure for vision restoration, exhibits variable outcomes based on patient demographics. This study aimed to elucidate the effects of age and sex on risk factors, intraoperative complications, and postoperative outcomes of cataract surgery. A single-center retrospective cohort study analyzed 691 eyes from 589 individuals who underwent surgery at a tertiary referral center, using electronic medical records to assess preoperative risk factors, intraoperative complications, and best corrected visual acuity (BCVA) pre- and post-operatively, alongside demographic data.
View Article and Find Full Text PDF: This study aimed to describe the clinical, optical coherence tomography (OCT) and OCT angiography (OCTA) findings and characteristics in patients with perifoveal exudative vascular anomalous complex (PEVAC) and compare the macular vascular density with the age-matched control group. : We conducted a case-control study to compare demographic information, clinical observations, and OCT/OCTA findings in eyes with PEVAC ( = 5 eyes in 5 patients) and a control group of subjects matched for age ( = 9). The Advanced Retina Imaging (ARI) network algorithms were utilized to evaluate OCTA observations.
View Article and Find Full Text PDFPurpose: Adult-onset foveomacular vitelliform dystrophy (AFVD) shares phenotypic similarities with age-related macular degeneration (AMD). The genetic factors associated with AFVD are unknown in >80% of cases. This study evaluated the association of known AMD genetic risk variants with AFVD and compared systemic complement activation in these conditions.
View Article and Find Full Text PDFArticle Synopsis
- * A total of 597 AMD patients were analyzed, with 332 having SDDs and 265 without, using optical coherence tomography (SD-OCT) and reviewing electronic medical records.
- * Results showed that AMD patients with SDDs are significantly more likely to be diagnosed with CVD and have procedures such as percutaneous transluminal coronary angioplasty (PTCA), suggesting a possible shared mechanism between SDDs and severe cardiovascular conditions.
Article Synopsis
- Age-related macular degeneration (AMD) is a complex eye disease influenced by both genetic factors and involves a subtype called reticular pseudodrusen (RPD), which increases the risk of severe vision loss.* -
- A genome-wide association study compared genetic data from individuals with AMD and/or RPD to controls, finding significant associations specifically on chromosome 10, while chromosome 1 did not show this correlation in RPD cases.* -
- The chromosome 10 region includes a long non-coding RNA related to retinal health, highlighting its potential role in retinal thickness and influencing the outer segment of photoreceptors.*