Publications by authors named "I C Pimentel"
Article Synopsis
- The study compared three types of bioreactors for producing L-asparaginase, an enzyme linked to treating leukemia and lymphoma.
- Cunninghamella echinulata DSM1905 was identified as the best strain for producing L-ASNase during initial screenings.
- Among the bioreactors tested, the hybrid fixed-bed airlift (FB-ALR) system resulted in the highest enzyme activity, suggesting it is the most effective method for enzyme production.
Sacituzumab govitecan (SG), a Trop-2-directed antibody-drug conjugate (ADC), was the first ADC approved for patients with metastatic triple-negative breast cancer (mTNBC) who had received at least two prior lines of therapy for advanced disease. Although SG has shown promising clinical activity in treating brain metastases in both ASCENT randomized trials and real-world analysis, its utility in leptomeningeal carcinomatosis (LC) remains underexplored. We report the diagnostic and therapeutic process of a patient who develops extensive LC from TNBC treated with SG.
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- Episodic memories are structured around event boundaries, which are times of environmental change, requiring the brain to rapidly reset for effective information encoding.
- Norepinephrine (NE) is believed to help reorganize neuronal networks during these changes, but its role in the hippocampus during event boundaries is still being explored.
- Research using a new sensor to measure NE in mice showed that NE release coincides with these environmental transitions, affecting hippocampal neural spiking patterns and potentially aiding long-term memory formation.
Purpose: To evaluate the efficacy and safety of the combination of olaparib plus trastuzumab in patients with HER2-positive advanced breast cancer (ABC) and germinal BRCA mutations (gBRCAm).
Methods: OPHELIA (NCT03931551) was a single-arm, open-label, phase 2 clinical trial. Patients aged ≥18 years diagnosed with HER2-positive ABC with germinal deleterious mutations in BRCA1 or BRCA2 who had received at least one prior systemic regimen for advanced disease were enrolled.
A multitude of anthropogenic stressors impact biological communities and ecosystem processes in urban streams. Prominent among them are salinization, increased temperature, and altered flow regimes, all of which can affect microbial decomposer communities and litter decomposition, a fundamental ecosystem process in streams. Impairments caused by these stressors individually or in combination and recovery of communities and ecosystem processes after release from these stressors are not well understood.
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