Publications by authors named "I C Paz"

Article Synopsis
  • High microglial diversity complicates the creation of targeted treatments for Alzheimer's disease (AD).
  • A comprehensive analysis of RNA-sequencing data revealed specific microglial subtypes associated with AD and identified potential drug targets, including microglial transition networks.
  • The study highlights ketorolac as a promising anti-inflammatory treatment for AD, showing its association with lower AD incidence in patient databases.
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The failure of achieving a penile erection for satisfactory sexual intercourse is known as erectile dysfunction (ED). The primary mediator for penile erection is nitric oxide (NO). ED is often associated with endothelial/nitrergic dysfunction characterized by a reduction of the bioavailability of NO.

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How the human brain processes information during different cognitive tasks is one of the greatest questions in contemporary neuroscience. Understanding the statistical properties of brain signals during specific activities is one promising way to address this question. Here we analyze freely available data from implanted electrocorticography (ECoG) in five human subjects during two different cognitive tasks in the light of information theory quantifiers ideas.

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Chemokine receptors play diverse roles in the immune response against pathogens by recruiting innate and adaptive immune cells to sites of infection. However, their involvement could also be detrimental, causing tissue damage and exacerbating respiratory diseases by triggering histological alterations such as fibrosis and remodeling. This chapter reviews the role of chemokine receptors in the immune defense against SARS-CoV-2 infection.

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