Publications by authors named "I C Nweze"

Background: Little is known about the factors responsible for the academic performance of clinical dentistry/dental surgery students, particularly those in their finals in Nigerian universities.

Objectives: The objectives of the study were to identify the subjective factors that may affect the performance of dental surgery finalists at the undergraduate level in Nigerian dental schools and to proffer realistic suggestions to improve dental surgery education.

Materials And Methods: A cross-sectional survey of final-year dental surgery students in Nigeria was conducted using a well-structured validated online questionnaire distributed randomly through online platforms.

View Article and Find Full Text PDF

Background: Alcohol-related trauma remains high among underserved patients despite ongoing preventive measures. Geographic variability in prevalence of alcohol-related injury has prompted reexamination of this burden across different regions. We sought to elucidate demographic and socioeconomic factors influencing the prevalence of alcohol-related trauma among underserved patients and determine alcohol effects on selected outcomes.

View Article and Find Full Text PDF

Background And Aims: Falls are a significant cause of mortality in the elderly patients. Despite this, the literature on in-hospital mortality related to elderly falls remains sparse. Our study aims to determine the risk factors associated with in-hospital mortality in elderly patients admitted to a regional trauma center after sustaining a fall.

View Article and Find Full Text PDF
Article Synopsis
  • Excessive iNOS-derived nitric oxide contributes to liver injury, dysfunction, inflammation, and increased mortality in animals following shock.
  • Cytokines activate iNOS in liver cells (hepatocytes), and while the signaling involved is not fully understood, previous research showed that Akt can inhibit this iNOS expression through cAMP and insulin pathways.
  • Inhibition of GSK3 reduces cytokine-induced nitric oxide and iNOS expression, while GSK3 activation increases iNOS levels, suggesting that GSK3 regulates this process via the phosphorylation of c-Jun, highlighting the complex interaction between these signaling pathways.
View Article and Find Full Text PDF