Publications by authors named "I C M Paterson"
Oral potentially malignant disorders (OPMD) are a group of lesions carrying the risk of developing into cancer. The gold standard to predict which lesions are more likely to undergo malignant transformation is the presence of dysplasia histologically. However, not all dysplastic lesions progress, and non-dysplastic lesions may also undergo malignant transformation.
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- Severe aortic stenosis (AS) is identified by a specific heart murmur pattern and a weak or absent second heart sound.
- Diagnosing AS severity involves echocardiography to assess blood flow and aortic valve area, which helps determine the need for treatment.
- The guide provides strategies for using various imaging techniques to accurately diagnose and evaluate the progression of AS, especially when measurements are inconsistent.
We describe the successful synthesis of the phormidolide A macrocycle as a crucial step toward its total synthesis and configurational assignment. Exhaustive exploration of macrocyclization strategies revealed the detrimental effects of a bulky protecting group on the C17 hydroxyl function, leading to the successful use of a C17 -methoxybenzyloxymethyl (PMBM) ether in the macrolactonization reaction. Further elaboration of the macrocycle with a truncated C18-C23 side chain afforded an advanced C1-C23 fragment of phormidolide A.
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- The study aimed to evaluate the accuracy of 40 predictive equations for estimating resting energy expenditure (REE) in women with breast cancer, comparing these predictions to measurements taken by indirect calorimetry.
- The analysis included data from 90 participants (24% survivors, 61.1% early-stage cancer), revealing that none of the equations provided accurate REE estimates both at the group and individual levels, with significant biases observed.
- These findings highlight the importance of using precise methods for calculating energy needs in women with breast cancer, as inaccuracies can impact treatment and recovery by influencing energy intake.
Phenotypic changes to endometrial epithelial cells underpin receptivity to embryo implantation at the onset of pregnancy but the effect of hyperglycemia on these processes remains poorly understood. Here, we show that physiological levels of glucose (5 mM) abolished receptivity in the endometrial epithelial cell line, Ishikawa. However, embryo attachment was supported by 17 mM glucose as a result of glucose flux through the hexosamine biosynthetic pathway (HBP) and modulation of cell function via protein O-GlcNAcylation.
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