Publications by authors named "I C K Deutsch"
Radiomics for differentiation of somatic mutation on CT scans of patients with pleural mesothelioma.
J Med Imaging (Bellingham)
November 2024
Purpose: The BRCA1-associated protein 1 () gene is of great interest because somatic () mutations are the most common alteration associated with pleural mesothelioma (PM). Further, germline mutation of the gene has been linked to the development of PM. This study aimed to explore the potential of radiomics on computed tomography scans to identify somatic gene mutations and assess the feasibility of radiomics in future research in identifying germline mutations.
View Article and Find Full Text PDFPurpose: To maximize the therapeutic ratio, it is important to identify adverse prognostic features in men with prostate cancer, especially among those with intermediate risk disease, which represents a heterogeneous group. These men may benefit from treatment intensification. Prior studies have shown pretreatment mpMRI may predict biochemical failure in patients with intermediate and/or high-risk prostate cancer undergoing conventionally fractionated external beam radiation therapy and/or brachytherapy.
View Article and Find Full Text PDFArticle Synopsis
- A phase 1 trial was conducted to assess the safety and early effectiveness of durvalumab (D) alone and in combination with BCG or EBRT for treating patients with non-muscle-invasive bladder cancer (NMIBC) who did not respond to standard BCG therapy.
- Patients received D every 3 weeks for eight cycles, with some also receiving BCG or EBRT, and outcomes were measured using cystoscopy, urine cytology, and bladder biopsies at 3 and 6 months.
- Results showed that 64% of patients achieved a complete response at 3 months, with notable responses in combination therapy groups, suggesting that D combined with BCG or EBRT is safe and warrants further investigation.
We introduce kicked p-spin models describing a family of transverse Ising-like models for an ensemble of spin-1/2 particles with all-to-all p-body interaction terms occurring periodically in time as delta-kicks. This is the natural generalization of the well-studied quantum kicked top (p=2) [Haake, Kuś, and Scharf, Z. Phys.
View Article and Find Full Text PDFPurpose: The rapid expansion of telemedicine has presented a challenge for the care of patients with genitourinary malignancies. We sought to assess patient and physician perspectives on the use of telemedicine for genitourinary cancer care.
Methods: We conducted a prospective cross-sectional study of patients who had telemedicine visits with urology, medical oncology, or radiation oncology for management of genitourinary malignancies from July-August 2020.