Publications by authors named "I C Iser"
Despite the emergence of the first human papillomavirus vaccine, the incidence of cervical cancer is still responsible for more than 350,000 deaths yearly. Over the past decade, ecto-5'-nucleotidase (CD73/5'-NT) and extracellular adenosine (ADO) signalling has been the subject of many investigations to target cancer progression. In general, the adenosinergic axis has been linked to tumourigenic effects.
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- Epithelial-mesenchymal transition (EMT) plays a crucial role in cancer progression, invasion, and resistance to therapy, making it an important target for cancer research.
- The CD73 enzyme has been linked to EMT, as it produces adenosine, which influences cell adhesion and migration, as well as having immunosuppressive effects.
- An analysis of RNA sequencing data identified a strong correlation between EMT scores and the expression of CD73 and CD39 in various cancers, especially prostate adenocarcinoma, indicating that the interplay between EMT and the adenosine signaling pathway varies by tumor context and could lead to new treatment approaches.
Many studies have shown that mesenchymal stromal cells (MSCs) and their secreted factors may modulate the biology of tumor cells. However, how these interactions happen in vivo remains unclear. In the present study, we investigated the effects of rat adipose-derived stromal cells (ADSCs) and their conditioned medium (ADSC-CM) in glioma tumor growth and malignancy in vivo.
View Article and Find Full Text PDFStem-like cells (CSCs) have a tumour-initiating capacity and play critical role in tumour metastasis, relapse and resistance to therapy. The ectoenzyme CD73, encoded by the NT5E gene, which catalyses the hydrolysis of AMP into adenosine, has been associated to an immunosuppressive tumour microenvironment, tumour cell adhesion and migration. Therefore, we investigated the expression and activity of CD73 in sphere-forming cells from cervical cancer in comparison to monolayer cells in vitro.
View Article and Find Full Text PDFMesenchymal stromal cells (MSCs) are promising candidates for cell-based therapies, mainly due to their unique biological properties such as multipotency, self-renewal and trophic/immunomodulatory effects. However, clinical use has proven complex due to limitations such as high variability of MSCs preparations and high number of cells required for therapies. These challenges could be circumvented with cell immortalization through genetic manipulation, and although many studies show that such approaches are safe, little is known about changes in other biological properties and functions of MSCs.
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