Model components of luminol chemiluminescence generated by PMNL.

The production of activated oxygen species (AOS) by neutrophils (PMNL) is thought to play a key role in the host defence against invading microorganisms. However, the oxygen metabolites are toxic not only to the invading bacteria but also to the surrounding tissue. The oxidative metabolites production can be evaluated by means of chemiluminescent methods.

[The level of mercapturic acids in the urine of workers in the petroleum refining industry].

Examination are carried out on 236 workers from three productions of oil-processing industry, who are exposed to the effect of hydrocarbons--saturated from the ethylene order, saturated (benzine), aromatic and sulphuric compounds--sulphur-containing organic, hydrogen sulphide, sulphur dioxide. The purpose of the study is to establish the risk of exposure to alkylating agents, which are potentially cancerogenic and mutagenic. Leading noxa in the production of high-octane aviation benzine (production "sulfur acidic alkylation", are the sulphur containing organic compounds, hydrogen sulphide, and in some working places--hydrocarbons (benzine and aromatic); in the production of "Ethylene" and "Polypropylene" leading noxae are the saturated hydrocarbons, and the sulphur-containing organic compounds as well as the unsaturated hydrocarbons (ethylene and propylene).

Thiol antidotes effect on lipid peroxidation in mercury-poisoned rats.

The effect of thiol antidotes 2,3-dimercapto-1-propanesulfonic acid (DMPS) and D-penicillamine (PA) on lipid peroxidation and on activities of some protecting enzymes in blood, liver and kidneys of mercury-poisoned rats has been studied. It has been found that Hg-poisoning is associated with increased lipid peroxidation in the liver and in the kidneys and with inactivation of superoxide dismutase (SOD) and catalase. Inhibition of SOD is caused by thiols treatment too, but in this case acceleration of lipid peroxidation has not been observed.

[Epidemiological studies on the manufacture of cross-linked polyethylene].

In the production of cross-linked polyethylene in the air of the working environment above the norm concentrations of acetophenon, dicumyl peroxide and antioxidant are established, which create unfavourable working conditions. During clinical and laboratory examinations of 55 workers, engaged in the production of cross-linked polyethylene, are registered subjective complaints from the irritating effect of the chemical noxae on the mucous membranes and skin. Methaemoglobinaemia is found in 4 workers.

[The relationship of exposure to chemically harmful compounds and disorders of the health status in workers in ethylene production].

On the basis of job characteristics of workers from the production "ethylene", chronometric studies and measurement of concentration from chemical compounds are developed professional diagrams and risk diagrams, which give a possibility for more precise account of the exposure to chemical noxious compounds (by figures). According to the values of the estimated total index of exposure 156 workers are distributed in 5 groups. Besides, 48 workers with prolonged length of service in the production and 37 persons control group are examined.