Publications by authors named "I Brunetti"
Aims: Chronic periodontitis is the sixth most prevalent disease worldwide and the leading cause of tooth loss in adults. With growing attention on the role of inflammatory and immune responses in its pathogenesis, there is an urgent need to evaluate host-modulatory agents. Non-steroidal anti-inflammatory drugs (NSAIDs) drugs play a crucial role in managing inflammatory conditions.
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- - This study examined the EzPAP Positive Airway Pressure System, a noninvasive device designed to help expand the lungs and improve gas exchange, particularly among spontaneously breathing patients with and without tracheostomy.
- - Conducted at a university hospital, the study found that while gas exchange did not significantly change in most patients after PEP, those with tracheostomy showed temporary improvement immediately after treatment, although it did not hold after two hours.
- - Ultimately, the study concluded that while lung expansion improved radiological scores within a week, the PEP therapy did not significantly alleviate respiratory distress in the subjects.
Bixin (CHO; 394.51 g/mol) is the main apocarotenoid found in annatto seeds. It has a 25-carbon open chain structure with a methyl ester group and carboxylic acid.
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- * Blood samples from 40 patients revealed that oxidative stress markers decreased and the enzyme paraoxonase-1 activity partially recovered after hemodialysis, indicating some improvement in oxidative status.
- * However, hemodialysis also led to a reduction in overall serum antioxidant potential, highlighting a complex relationship between dialysis treatment and oxidative stress that requires further investigation.
Lycopene in Combination with Insulin Triggers Antioxidant Defenses and Increases the Expression of Components That Detoxify Advanced Glycation Products in Kidneys of Diabetic Rats.
Nutrients
May 2024
Background: Biochemical events provoked by oxidative stress and advanced glycation may be inhibited by combining natural bioactives with classic therapeutic agents, which arise as strategies to mitigate diabetic complications. The aim of this study was to investigate whether lycopene combined with a reduced insulin dose is able to control glycemia and to oppose glycoxidative stress in kidneys of diabetic rats.
Methods: Streptozotocin-induced diabetic rats were treated with 45 mg/kg lycopene + 1 U/day insulin for 30 days.