Publications by authors named "I Bramuzzo"
Purpose: Differentiating infectious from non-infectious respiratory syndromes is critical in emergency settings. This study aimed to assess whether nCD64 and mCD169 exhibit specific distributions in patients with respiratory infections (viral, bacterial, or co-infections) and to evaluate their diagnostic accuracy compared to non-infectious conditions.
Methods: A prospective cohort study enrolled 443 consecutive emergency department patients with respiratory syndromes, categorized into four groups: no infection group (NOIG), bacterial infection group (BIG), viral infection group (VIG), and co-infection group (COING).
S. aureus bacteremia with acute transverse myelitis case report: Utility of molecular techniques.
J Infect Chemother
February 2025
Article Synopsis
- A 60-year-old man experienced bacteremia and acute transverse myelitis (ATM) due to Staphylococcus aureus, presenting with symptoms like high fever, quadriplegia, and respiratory failure, without a clear source of infection.
- Bacterial ATM is rare and often difficult to diagnose, especially when caused by isolated infections in the spinal cord.
- The rapid diagnosis in this case resulted from teamwork among clinicians, infectious disease specialists, and microbiologists, along with advanced testing methods on cerebral spinal fluid (CSF).
Background: The expression of CD64 on neutrophils (nCD64), measured using flow cytometry, has been proposed as a biomarker for bloodstream infections (BSI). However, data regarding its use in the setting of liver cirrhosis are lacking.
Methods: We compared nCD64 levels in 15 cirrhotic patients with BSI to those in 19 controls, including outpatients with stable decompensated cirrhosis without infection.
Article Synopsis
- Dalbavancin is a long-acting antibiotic effective for treating acute bacterial skin infections, which helps address hospital bed shortages.
- During 2017-2023, strategies implemented in hospitals saved over 1,400 hospitalization days by efficiently managing patient admissions and discharges.
- The treatment showed a 99.5% success rate, with minimal minor side effects, making it a strong option for managing infections in resource-limited healthcare settings.
Staphylococcus aureus bacteremia presents clinical complexities, with prolonged duration associated with unfavorable outcomes. This research delves into unconventional treatments, such as combinations involving daptomycin, oxacillin, ceftaroline, and fosfomycin, with the aim of swiftly sterilizing bloodstream infection to reduce complications. Our examination of 30 MSSA bacteremia patients with infective endocarditis uncovers differing results between single-agent therapies (oxacillin or daptomycin) and combined treatment plans.
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