Psoriasis induced by tumor necrosis factor-alpha antagonist therapy: a case series.

Objective: Although tumor necrosis factor-alpha (TNF-alpha) antagonists are effective in the treatment of refractory psoriasis, some cases have suggested that psoriasis might be induced as a result of treatment prescribed mainly for rheumatoid arthritis, ankylosing spondylitis, and Crohn's disease. To investigate anti-TNF-alpha induced psoriasis, we conducted a systematic analysis of the 6 cases we observed among our inflammatory patient cohort treated with anti-TNF-alpha (infliximab or etanercept).

Methods: We report 6 cases of psoriasis with onset during TNF-alpha antagonist therapy (infliximab and etanercept); characteristics and skin lesions are described.

[Methotrexate therapy in psoriasis].

Methotrexate is a good treatment for severe psoriasis. Low-dose, once a week treatment is safe if guidelines are followed. Hematologic toxicity occurs especially if other drugs are associated.