Publications by authors named "I Bortone"
Air pollutants and ovarian reserve: a systematic review of the evidence.
Front Public Health
October 2024
Background: Growing evidence indicates an association between ambient air pollution and decreased human reproductive potential. This study aims to systematically review the association between air pollutants and female ovarian reserve.
Methods: The literature was searched in six electronic databases through June 2024.
Article Synopsis
- Recent efforts to find effective Alzheimer's Disease (AD) treatments targeting amyloid-β (Aβ), tau protein, and neuroinflammation have largely failed, particularly with anti-Aβ monoclonal antibodies like solanezumab.
- The text reviews the failures of solanezumab in clinical trials, including its pharmacokinetics and impacts on cognitive functions, highlighting disappointing outcomes like accelerated cognitive decline.
- The failure of solanezumab raises critical questions about the Aβ cascade hypothesis of AD, suggesting that targeting Aβ alone may not be sufficient for treatment.
Sporadic Alzheimer's disease (AD) derives from an interplay among environmental factors and genetic variants, while epigenetic modifications have been expected to affect the onset and progression of its complex etiopathology. Carriers of one copy of the apolipoprotein E gene () allele have a 4-fold increased AD risk, while -carriers have a 12-fold increased risk of developing AD in comparison with the -carriers. The main longevity factor is the homozygous ε3/ε3 genotype.
View Article and Find Full Text PDFThe conceptual change of frailty, from a physical to a biopsychosocial phenotype, expanded the field of frailty, including social and behavioral domains with critical interaction between different frailty models. Environmental exposures - including physical exercise, psychosocial factors and diet - may play a role in the frailty pathophysiology. Complex underlying mechanisms involve the progressive interactions of genetics with epigenetics and of multimorbidity with environmental factors.
View Article and Find Full Text PDF