Immune response to keyhole limpet hemocyanin and oral Actinomyces viscosus antigens in Macaca arctoides.

The humoral and cell-mediated immune response to keyhole limpet hemocyanin and antigens from a monkey oral strain of Actinomyces viscosus were investigated in Macaca arctoides. Prior to immunization no responses were detected. Immunization resulted in the production of antibodies to both antigen preparations, the development of a positive skin test and significant stimulation of peripheral blood lymphocytes using the in vitro lymphocyte blastogenesis technique.