MAPT Q336H mutation: Intrafamilial phenotypic heterogeneity in a new Italian family.

Background And Purpose: Q336H is a rare MAPT mutation, previously found in a single patient with behavioral variant frontotemporal dementia and tau pathology (Pick bodies). Here, we describe the clinical characteristics of two members of a new family carrying the Q336H MAPT mutation.

Methods: Clinical, genetic, and neuroradiological assessment and follow-up of the proband were made.

On which abilities are category fluency and letter fluency grounded? A confirmatory factor analysis of 53 Alzheimer's dementia patients.

Background/aims: In Alzheimer's dementia (AD), letter fluency is less impaired than category fluency. To check whether category fluency and letter fluency depend differently on semantics and attention, 53 mild AD patients were given animal and letter fluency tasks, two semantic tests (the Verbal Semantic Questionnaire and the BORB Association Match test), and two attentional tests (the Stroop Colour-Word Interference test and the Digit Cancellation test).

Methods: We conducted a LISREL confirmatory factor analysis to check the extent to which category fluency and letter fluency tasks were related to semantics and attention, viewed as latent variables.

Autobiographical memory in amnestic Mild Cognitive Impairment.

Autobiographical memory (ABM) was evaluated in 19 patients with amnestic Mild Cognitive Impairment (aMCI) by means of the standardized enquiry developed by Borrini et al. (Psychol Med 19:215-224, 1989). Longitudinal assessments were carried out by re-testing participants at 9-month intervals up to three assessments over 18 months.

Mild cognitive impairment does entail retrograde amnesia for public events.

In this study memory for public events was evaluated in 15 amnesic mild cognitive impairment (aMCI) patients, whose clinical diagnosis was refined through a stringent selection procedure. A total of 9 patients were longitudinally reassessed over an 18-month period. About half of the participants were impaired at baseline and nearly 80% at the end of the 18-month follow-up.