Publications by authors named "I Bisceglia"
This study aimed to assess whether multidisciplinary team (MDT) management improves outcomes in patients with stage I-III colorectal cancer (CRC) compared to non-MDT care. This study included 460 CRC patients diagnosed from 2017 to 2018 in a northern Italian province, of whom 300 (65%) were managed by MDT. MDT patients were younger, more frequently had rectal cancers, were diagnosed at earlier stages, and were more likely to undergo surgery and chemotherapy.
View Article and Find Full Text PDFPurpose: This study aimed to develop a multivariable, weighted overall survival (OS) risk score (SRS) for nonmetastatic (M0) invasive breast cancer (M0-BC, SRS).
Materials And Methods: This study included a training (1,890 patients) and a validation cohort (850 patients) from the Reggio Emilia Cancer Registry (RE-CR). Ten traditional prognostic variables were evaluated.
A Population-Based Analysis of the Cancer Incidence in Individuals under 50 in a Northern Italian Province: Focusing on Regional Disparities and Public Health Implications.
Int J Environ Res Public Health
October 2024
Article Synopsis
- International studies indicate a rising cancer rate among young adults, prompting this research into cancer incidence trends for ages 15-49 in Northern Italy from 1996 to 2021.
- Males showed a slight increase in overall cancer incidence up to 2013, followed by a decline, while females experienced a consistent modest rise; lung cancer was decreasing in both sexes.
- The study highlights significant changes in specific cancers, such as an increase in testicular cancer and melanoma, and emphasizes the need for promoting healthy lifestyles to combat these trends.
Cancer patients, especially long cancer survivors, are exposed to several cardio-metabolic diseases, including diabetes, heart failure, and atherosclerosis, which increase their risk of cardiovascular mortality. Therapy with glucagon-like peptide 1 (GLP1) receptor agonists demonstrated several beneficial cardiovascular effects, including atherosclerosis and heart failure prevention. Cardiovascular outcome trials (CVOTs) suggest that GLP-1 RA could exert cardiorenal benefits and systemic anti-inflammatory effects in patients with type-2 diabetes through the activation of cAMP and PI3K/AkT pathways and the inhibition of NLRP-3 and MyD88.
View Article and Find Full Text PDFArticle Synopsis
- Immunotherapy has improved cancer treatment, resulting in many patients experiencing long-term survival or even cures.
- There is evidence suggesting that immune checkpoint inhibitors, which help fight cancer, may worsen atherosclerosis and increase the risk of cardiovascular issues due to shared molecular mechanisms and chronic inflammation.
- Due to the rise in cancer patients receiving immunotherapy, it is crucial to understand the potential cardiovascular risks associated with treatment and implement preventative measures to address atherosclerosis-related complications.