Publications by authors named "I Bhattacharyya"
Jaw osteosarcoma (JOS) is a rare, distinct variant that differ from long bone osteosarcoma (LBOS) in several aspects. JOS typically appears about twenty years later than LBOS, displays a lower propensity for metastasis to other organs, and exhibits better survival rates. The dissimilarities in clinical and biological behavior between JOS and LBOS are likely due, at least in part, to variations in their respective microenvironments.
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- - Sjögren's disease (SD) is an autoimmune condition linked to specific autoantibodies, and a case study showed that a previously healthy individual developed SD after primary Epstein-Barr virus (EBV) infection, resulting in multiple autoantibody productions.
- - Researchers examined immune responses to various autoantigens and found that anti-Ro52 and anti-Ro60 autoantibodies started to appear shortly after EBV infection, with levels continuing to rise alongside other antibodies long after the initial infection.
- - The study concludes that EBV infection can trigger specific autoantibody responses through different mechanisms, and it notes that some healthy individuals can produce certain autoantibodies independently of the EBV response.
Single-Cell Transcriptomics Reveals a Pivotal Role of DOCK2 in Sjögren Disease.
ACR Open Rheumatol
December 2024
Article Synopsis
- Sjögren disease (SjD) is an autoimmune disorder affecting salivary and tear glands; the study focused on understanding the immune cell types and their pathways involved in this condition.
- Researchers used single-cell RNA sequencing to analyze immune cell compositions in SjD mouse models, identifying key cell populations and their specific genes associated with the disease.
- Treatment with a DOCK2 inhibitor showed promising results in reducing SjD symptoms, suggesting that targeting DOCK2 could be a viable strategy for improving treatment outcomes in SjD patients.
Article Synopsis
- Juvenile ossifying fibroma (JOF) is a rare, benign growth in the jaw area that can be aggressive and likely to come back after treatment; it shares some traits with low-grade intramedullary osteosarcoma (LGIOS).
- The study investigated 9 JOF cases for the presence of MDM2 gene locus amplification using a method called fluorescence in-situ hybridization (FISH), which is important for analyzing certain tumors.
- Results showed that none of the JOF cases had MDM2 gene amplification, indicating a different underlying cause compared to LGIOS, suggesting that this finding could help differentiate between these similar conditions in future diagnoses.
Background: Childhood Sjögren's disease is a rare, underdiagnosed, and poorly-understood condition. By integrating machine learning models on a paediatric cohort in the USA, we aimed to develop a novel system (the Florida Scoring System) for stratifying symptomatic paediatric patients with suspected Sjögren's disease.
Methods: This cross-sectional study was done in symptomatic patients who visited the Department of Pediatric Rheumatology at the University of Florida, FL, USA.