Development and validation of DNA methylation scores in two European cohorts augment 10-year risk prediction of type 2 diabetes.

Type 2 diabetes mellitus (T2D) presents a major health and economic burden that could be alleviated with improved early prediction and intervention. While standard risk factors have shown good predictive performance, we show that the use of blood-based DNA methylation information leads to a significant improvement in the prediction of 10-year T2D incidence risk. Previous studies have been largely constrained by linear assumptions, the use of cytosine-guanine pairs one-at-a-time and binary outcomes.

Reorganization of an Emergency Medical System in a Mixed Urban-Rural Area.

The reorganization of an emergency medical system means that we look for new locations of ambulance stations with the aim of improving the accessibility of the service. We applied two tools that are well known in the operations research community, namely mathematical programming, and computer simulation. Using the hierarchical -median model, we proposed optimal locations of the stations throughout the country and within large towns.

Embryonic exposure to low concentrations of aflatoxin B1 triggers global transcriptomic changes, defective yolk lipid mobilization, abnormal gastrointestinal tract development and inflammation in zebrafish.

Aflatoxin B1-contaminated feeds and foods induce various health problems in domesticated animals and humans, including tumor development and hepatotoxicity. Aflatoxin B1 also has embryotoxic effects in different livestock species and humans. However, it is difficult to distinguish between the indirect, maternally-mediated toxic effects and the direct embryotoxicity of aflatoxin B1 in mammals.

[Inspection of surgical rubber gloves used during dental procedures].

The resistance and durability of operating rubber gloves (PALMA) during different types of dental treatment were investigated. Six percent of the rubber gloves were found to be defective. One pair of gloves could be used 2.