[Iatrogenic colorectal perforations--review of cases of the last twenty years].

The experiences with the surgical therapy of 31 patients treated for iatrogenic colorectal perforations during twenty years (1979-1998) are reviewed by the authors. The factors leading to perforation and applied types of operations compared with the therapeutical methods suggested by the literature are summarized. For the treatment of immediately detected instrumental perforations of the well cleaned colon the justification of the suture and primary resection is stressed.

Changes in apoptotic and mitotic activity in rectal carcinoma after short-term cytostatic therapy as possible predictive factors.

Fifteen patients with rectal adenocarcinoma were endoscopically biopsied and given short-term [5 fluorouracil (5FU) (600 mg/m2) and Ca-Folinate (60 mg/m2) for two days] cytostatic therapy. Seven days later the tumor was resected or a second biopsy was performed. Apoptotic and mitotic indices were determined in the tumor tissue before and after the short-term chemotherapy.

The relationship between splanchnic oxygen consumption and blood supply.

Our experimental study has proved, that the increase in the intestinal and splanchnic metabolism is associated with raised blood flow. However, it has been found that so called primary increase of the blood flow by the administration of vasodilatators is not associated with raised metabolism, i.e.

Effect of acidification of the duodenal contents on splanchnic circulation and metabolism.

Portal vein (PF) and superior mesenteric artery blood flows (SMAF), arterial and portal venous oxygen concentrations were measured in dogs before and after duodenal introduction of 3 ml/kg 0.1 mol HCl. The duodenal acidification increased PF by 30% and SMAF by 35%.

Circulatory effects of intraduodenal acidification in the rat.

The effect of intraduodenal administration of 0.3 ml/100 g 0.1 N hydrochloric acid and of the i.