Publications by authors named "I Benesova"
Background: Chest wall sarcomas are rare and pose significant technical challenges in surgical management, particularly in patients with advanced disease. In this study, we examined the extent of resection, reconstruction techniques, and oncological outcomes of patients with chest wall soft tissue and bone sarcomas.
Methods: This retrospective single-center series included patients who underwent surgery at our center between May 2014 and February 2022 for deep-seated/subfascial primary and recurrent soft tissue or bone sarcomas of the chest wall requiring significant resection and extensive reconstruction.
Article Synopsis
- Prostate cancer (PCa) has an immunosuppressive environment that limits immune activation, resulting in reduced activity of cytotoxic T-cells and increased levels of regulatory T cells (Tregs) and tumor-associated macrophages (TAMs), which are linked to poorer outcomes.
- The review emphasizes the role of different immune cells, including beneficial Th1 and harmful Th17 cells, in influencing tumor behavior, and how PCa's low immunogenicity poses challenges for immunotherapy.
- Chemotherapy is shown to have the potential to enhance the immune response against tumors by transforming the "cold" tumor microenvironment into a "hot" one, improving treatment efficacy by targeting immunosuppressive cells.
Purpose: The IMMUNOSARC trial combined an antiangiogenic agent (sunitinib) with a PD1 inhibitor (nivolumab) in advanced sarcomas. Here, we present the first correlative studies of the soft-tissue sarcoma cohort enrolled in this trial.
Experimental Design: Formalin-fixed paraffin-embedded and peripheral blood samples were collected at baseline and week 13.
IL-32 expression is important for pathogen clearance but detrimental in chronic inflammation, autoimmunity, and cancer. T cells are major IL-32 producers in these diseases and key mediators of pathogen and tumor elimination but also autoimmune destruction. However, their contribution to IL-32 biology during immune responses is hardly understood due to several isoforms with divergent inflammatory properties.
View Article and Find Full Text PDFHead and neck squamous cell carcinoma (HNSCC) is one of the most common tumor entities worldwide, with human papillomavirus (HPV) infection contributing to cancer development. Conventional therapies achieve only limited efficiency, especially in recurrent or metastatic HNSCC. As the immune landscape decisively impacts the survival of patients and treatment efficacy, this study comprehensively investigated the immunological tumor microenvironment (TME) and its association with patient outcome, with special focus on several dendritic cell (DC) and T lymphocyte subpopulations.
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