Publications by authors named "I Bartella"
Background: The optimal time to surgery (TTS) after neoadjuvant chemoradiotherapy (nCRT) for oesophageal cancer is unknown and has traditionally been 4-6 weeks in clinical practice. Observational studies have suggested better outcomes, especially in terms of histological response, after prolonged delay of up to 3 months after nCRT. The NeoRes II trial is the first randomised trial to compare standard to prolonged TTS after nCRT for oesophageal cancer.
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- Anastomotic leakage (AL) is a common and serious complication after Ivor-Lewis esophagectomy, and this study analyzes a new classification system for managing AL based on treatment options.
- The study examined 954 patients, revealing that most leaks were type II (endoscopic intervention), with type III (surgical intervention) being diagnosed earlier but associated with higher organ failure rates.
- The researchers concluded that while the new classification is easy to use and helps differentiate severity, it doesn't provide a clear treatment algorithm for managing AL.
Background: Anastomotic leakage is the most important surgical complication following esophagectomy. A major cause of leakage is ischemia of the gastric tube that is used for reconstruction of the gastrointestinal tract. Generalized cardiovascular disease, expressed by calcifications of the aorta and celiac axis stenosis on a pre-operative CT scan, is associated with an increased risk of anastomotic leakage.
View Article and Find Full Text PDFBackground: In recent years, minimally invasive Ivor Lewis (IL) esophagectomy with high intrathoracic anastomosis has emerged as surgical standard of care for esophageal cancer in expert centers. Alongside this process, many divergent technical aspects of this procedure have been devised in different centers. This study aims at achieving international consensus on the surgical steps of IL reconstruction using Delphi methodology.
View Article and Find Full Text PDFObjective: To investigate if prolonged TTS after completed nCRT improves postoperative outcomes for esophageal and esophagogastric junction cancer.
Summary Of Background Data: TTS has traditionally been 4-6 weeks after completed nCRT. However, the optimal timing is not known.