Publications by authors named "I Barone"
Article Synopsis
- Endocrine therapy improves outcomes for ERα+ breast cancer, but resistance remains a key challenge, often linked to mutations like Y537S in the hormone-binding domain of ERα.
- Researchers conducted coculture experiments to study interactions between mutant breast cancer cells (MCF-7YS) and fibroblasts (both normal and cancer-associated) to see how these interactions influence cancer progression.
- The study found that the Y537S mutation led to changes in fibroblast behavior and protein expression, with increased YAP1 involvement, suggesting that mutant breast cancer cells can enhance their growth and invasion capabilities through interactions with the tumor microenvironment.
Article Synopsis
- The study investigates the long-term effects of selective thinning around pedunculate oak on the diversity of epiphytes and tree-related microhabitats (TreMs) in Latvia's boreal-nemoral forest zone.
- Results show that, 20 years after thinning, there were no significant changes in overall epiphyte or TreM diversity; however, managed trees had a higher prevalence of common microhabitats.
- The authors recommend future research to monitor post-thinning conditions more systematically to better inform adaptive habitat management strategies and improve forest management practices.
Background: Bronchiectasis is a chronic respiratory condition characterised by airway and systemic inflammation with prevalence increasing with age. Given the median age of the patients, it is common to observe the presence of comorbidities, particularly cardiovascular diseases, which have been linked to adverse clinical outcomes. To investigate the pooled estimates of the association between bronchiectasis and coronary heart disease or stroke within this population, we conducted a systematic review and meta-analysis of the available scientific evidence.
View Article and Find Full Text PDFLung transplantation offers a lifesaving option for patients with end-stage lung disease, but it is marred by a high risk of post-transplant infections, particularly involving multidrug-resistant bacteria, Cytomegalovirus, and fungal pathogens. This elevated infection rate, the highest among solid organ transplants, poses a significant challenge for clinicians, particularly within the first year post-transplantation, where infections are the leading cause of mortality. The direct exposure of lung allografts to the external environment exacerbates this vulnerability leading to constant immune stimulation and consequently to an elevated risk of triggering alloimmune responses to the lung allograft.
View Article and Find Full Text PDFArticle Synopsis
- * By overexpressing FoxO3a in TamR-BCCs, researchers found it reduced their oxygen consumption and glycolytic rates, lowering their metabolic activity and promoting glucose accumulation.
- * Proteomic analysis indicated that FoxO3a decreased levels of important enzymes related to carbohydrate metabolism, suggesting that drugs that activate FoxO3a could be beneficial for treating patients resistant to antiestrogen therapy.