Publications by authors named "I Barak"
During sporulation, Bacillus subtilis forms an asymmetric septum, dividing the cell into two compartments, a mother cell and a forespore. The site of asymmetric septation is linked to the membrane where FtsZ and SpoIIE initiate the formation of the Z-ring and the E-ring, respectively. These rings then serve as a scaffold for the other cell division and peptidoglycan synthesizing proteins needed to build the septum.
View Article and Find Full Text PDFspores are considered to be efficient and useful vehicles for the surface display and delivery of heterologous proteins. In this study, we prepared recombinant spores with the receptor binding domain (RBD) of the SARS-CoV-2 spike glycoprotein displayed on their surface in fusion with the CotZ or CotY spore coat proteins as a possible tool for the development of an oral vaccine against the SARS-CoV-2 virus. The RBD was attached to the N-terminus or C-terminus of the coat proteins.
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- Streptococcus agalactiae (GBS) is a significant cause of infections in newborns and can also colonize adults in the gastrointestinal and urogenital tracts, leading to complicated antibiotic treatments due to resistant strains.
- Researchers isolated a unique endolysin called EN534 from a human strain of GBS, which has a structure designed for breaking down bacterial cell walls.
- The EN534 endolysin showed effectiveness in lysing GBS and other bacteria without harming beneficial vaginal bacteria, suggesting its potential as a new treatment option for GBS infections.
Article Synopsis
- The European XFEL and LCLS II are powerful X-ray sources that can collect detailed data from crystals at rapid megahertz rates.
- Researchers used these X-ray pulses to gather two complete datasets from a single lysozyme crystal in less than 1 microsecond, achieving high-resolution structures.
- The comparison of these structures showed no radiation damage or significant changes, indicating that this multi-hit SFX technique can effectively capture fast structural changes in crystals.
Objectives: To develop and validate a prediction model to estimate overall survival (OS) with and without postoperative radiotherapy (PORT) for resected major salivary gland (SG) cancers.
Materials And Methods: Adults in the National Cancer Database diagnosed with invasive non-metastatic major SG cancer between 2004 and 2015 were identified. Exclusion criteria included prior malignancy, pT1N0 or unknown stage, no or unknown surgery, and neoadjuvant therapy.