Publications by authors named "I Bakir"
Introduction: The evolving landscape of inflammatory bowel disease (IBD) necessitates refining colonoscopic surveillance guidelines. This study outlines methodology adopted by the British Society of Gastroenterology (BSG) Guideline Development Group (GDG) for updating IBD colorectal surveillance guidelines.
Methods And Analysis: The 'Grading of Recommendations, Assessment, Development and Evaluation' (GRADE) approach, as outlined in the GRADE handbook, was employed.
Article Synopsis
- Patients with inflammatory bowel disease (IBD) face an increased risk of colorectal cancer (CRC), which is heightened for those with low-grade dysplasia (LGD).
- A study involving 122 patients revealed that the burden of somatic copy number alterations (CNAs) in LGD lesions can significantly predict future cancer development, outperforming traditional clinical risk factors.
- The research suggests that measuring CNAs in LGD lesions is a cost-effective method for assessing CRC risk, allowing for better management of high-risk patients while reducing unnecessary treatments for those at low risk.
Article Synopsis
- Colonoscopic surveillance is important for patients with colonic inflammatory bowel disease (IBD) due to their higher risk of colorectal cancer (CRC), and a new prediction model has been developed for assessing this risk.
- The study analyzed data from 6 cohorts across North America and Europe, including 3731 patients, to create and validate this model using predictive variables and a statistical approach known as Cox proportional hazards modeling.
- The model showed good accuracy in predicting advanced colorectal neoplasia (aCRN) over 5-10 years, but further research is needed to validate its effectiveness across different populations and to determine how it impacts surveillance strategies.
Due to their increased cancer risk, patients with longstanding inflammatory bowel disease are offered endoscopic surveillance with concomitant histopathologic assessments, aimed at identifying dysplasia as a precursor lesion of colitis-associated colorectal cancer. However, this strategy is beset with difficulties and limitations. Recently, a novel classification criterion for colitis-associated low-grade dysplasia has been proposed, and an association between nonconventional dysplasia and progression was reported, suggesting the possibility of histology-based stratification of patients with colitis-associated lesions.
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