Ultrasound Biomicroscopy in scleral fixation using Gore-Tex suture of a subluxated PCIOL.

Introduction: The aim of our study was to assess the outcome of Gore-Tex sutures in minimally invasive scleral fixation of subluxated posterior chamber intraocular lenses (PCIOLs) and to demonstrate a method for validating the lens position.

Methods: Retrospective study of patients who underwent lasso in-the-bag scleral fixation of a subluxated PCIOL using the snare technique with Gore-Tex suture from 2019 to 2021 in a single tertiary medical center. Functional outcome was analyzed by clinical assessment, and anatomical outcome, by ultrasound biomicroscopy (UBM).

GraphVelo allows inference of multi-modal single cell velocities and molecular mechanisms.

RNA velocities and generalizations emerge as powerful approaches for exacting dynamical information from high-throughput snapshot single-cell data. Several inherent limitations restrict applying the approaches to genes not suitable for RNA velocity inference due to complex transcriptional dynamics, low expression, or lacking splicing dynamics, and data of non-transcriptomic modality. Here, we present GraphVelo, a graph-based machine learning procedure that uses RNA velocities inferred from existing methods as input and infer velocity vectors lie in the tangent space of the low-dimensional manifold formed by the single cell data.

An international study of clinical, demographic, and competence-related determinants of communication with professionals.

Purpose: This study aims to identify a combination of clinical, demographic, and patient competence determinants of patients' communication with doctors and nurses in an international sample of cancer patients.

Methods: For our cross-sectional study, cancer patients assessed their communication with their doctors or nurses at the start of their treatment. Patients completed EORTC communication questionnaire QLQ-COMU26 to assess ten areas of communication with their doctor or nurses plus another item to assess how competent they felt when communicating with professionals.

Intraocular lens power calculation accuracy in patients with keratoconus: Network meta-analysis and systematic review.

Background: Accurate intraocular lens (IOL) calculation in eyes with keratoconus (KCN) poses significant challenges. While various formulas, including KCN-specific ones, have been investigated, the optimal calculation method remains inconclusive.

Methods: The study was pre-registered in PROSPERO (CRD42023483119).

Global hinge sites of proteins as target sites for drug binding.

Hinge sites of proteins play a key role in mediating conformational mechanics. Among them, those involved in the most collective modes of motion, also called global hinges, are of particular interest, as they support cooperative rearrangements that are often functional. Yet, the utility of targeting global hinges for modulating function remains to be established.