Publications by authors named "I BOLL"
Article Synopsis
- Synaptic transmission in the nervous system is rapid and dynamic, previously thought to be regulated primarily by protein interactions and phosphorylation.
- This research introduces sialylation of -linked glycosylation as a potential new modulator of neurotransmitter release, showing that negatively charged sialic acids can be altered by sialyltransferases and sialidases.
- Using quantitative sialiomics, the study identified 1965 formerly sialylated glycosites in synaptic proteins, revealing that 430 of these sites changed after a 5-second depolarization, impacting key proteins involved in synaptic function.
Interleukin-6 (IL-6) signaling is a crucial regulatory event important for many biological functions, such as inflammation and tissue regeneration. Accordingly, several pathological conditions are associated with dysregulated IL-6 activity, making it an attractive therapeutic target. For instance, blockade of IL-6 or its α-receptor (IL-6R) by monoclonal antibodies has been successfully used to treat rheumatoid arthritis.
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- Exploring post-translational modifications (PTMs) through mass spectrometry (PTMomics) is gaining traction for its ability to analyze protein function and disease through detailed quantification of PTMs.
- Changes in PTMs can influence health and disease, making them vital for understanding biomarkers and disease mechanisms.
- Recent advancements allow for the simultaneous study of multiple PTMs from small sample sizes, enhancing research potential in personalized medicine and addressing current challenges in the field.
Soluble Interleukin-6 receptor (sIL-6R) mediated trans-signaling is an important pro-inflammatory stimulus associated with pathological conditions, such as arthritis, neurodegeneration and inflammatory bowel disease. The sIL-6R is generated proteolytically from its membrane bound form and A Disintegrin And Metalloprotease (ADAM) 10 and 17 were shown to perform ectodomain shedding of the receptor in vitro and in vivo. However, under certain conditions not all sIL-6R could be assigned to ADAM10/17 activity.
View Article and Find Full Text PDFTen genes (ANK1, bR10D1, CA3, EPOR, HMGA2, MYPN, NME1, PDGFRA, ERC1, TTN), whose candidacy for meat-quality and carcass traits arises from their differential expression in prenatal muscle development, were examined for association in 1700 performance-tested fattening pigs of commercial purebred and crossbred herds of Duroc, Pietrain, Pietrain x (Landrace x Large White), Duroc x (Landrace x Large White) as well as in an experimental F(2) population based on a reciprocal cross of Duroc and Pietrain. Comparative sequencing revealed polymorphic sites segregating across commercial breeds. Genetic mapping results corresponded to pre-existing assignments to porcine chromosomes or current human-porcine comparative maps.
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