The person-based approach to intervention development: A scoping review of methods and applications.

Background: The person-based approach (PBA) has emerged as a prominent methodology guiding the development of digital and hybrid health behaviour change interventions over the last decade, and there is a salient need to understand its utilization.

Objective: This study aims to describe which elements of the PBA have been utilised in intervention development research, for which populations, and how this has been reported.

Methods: A search for intervention development papers published between 2015 and 2023 using forward citation searches was undertaken in Scopus, using two seed articles.

The Use of MPS in Three Rs and Regulatory Applications: Perspectives From Developers on Stakeholder Responsibilities.

Increasing the use of microphysiological systems (MPS) in Three Rs and regulatory applications is a nuanced but important goal, which would also help increase their scientific impact. There are three distinct and important stakeholder groups that each play a unique role in expediting the use of MPS for regulatory purpose - namely, commercial MPS developers, end-users and regulators. Additionally, non-profit organisations, such as the 3Rs Collaborative (3RsC), can help coordinate these efforts.

Historical mining towns: The establishment of 'Soil Planning Areas' for the risk management of contaminated soil.

Historical mining towns face financial challenges with the proposed Soil Monitoring Law of the European Union, which will require the management of soil contamination, since remediating soil in densely populated towns and cities is challenging. We compared the environmental impact of sulfide ore mining in the urban area of Outokumpu in Finland with that of other European sites, focusing on soil contamination. Soil sampling revealed that mine tailings were historically used in road construction.

Clinical relevance of feto-maternal microchimerism in (hematopoietic stem cell) transplantation.

Toleration of a semi-allogeneic fetus in the mother's uterus as well as tolerance after allogeneic hematopoietic stem cell transplantation (HSCT) appear to share some immunologic concepts. The existence of microchimeric cells, and the original idea of a bidirectional cell trafficking between mother and child during pregnancy have been known for decades. Today, origins and mechanisms of persistence of microchimeric cells are intensively being elucidated.