Human circulating plasma DNA significantly decreases while lymphocyte DNA damage increases under chronic occupational exposure to low-dose gamma-neutron and tritium β-radiation.

The blood plasma of healthy people contains cell-fee (circulating) DNA (cfDNA). Apoptotic cells are the main source of the cfDNA. The cfDNA concentration increases in case of the organism's cell death rate increase, for example in case of exposure to high-dose ionizing radiation (IR).

[Molecular-genetic and epidemiologic examination of personnel subjected to occupational irradiation in Russian Federal Nuclear Center (Sarov). Report 3. Genetic characteristics of adaptive norm].

Was undertaken the effort to define the limits of the adaptive norms and of high risk groups in regard to the work connected with fissile materials (FM), radioactive materials (RM) and ionizing radiation sources (IRS). In view of the aforementioned goal it was made a comparative evaluation of the individual radiosensitivity measurements and anthropometric indicators in the cohort formed from VNIIEF personnel, which was exposed to a constant occupational gamma-neutron irradiation, as well as the non-irradiated cohort. There were analyzed the dispersion dependencies on height, on chest and on head circumference and heterozygosis by 9 loci.

[Molecular-genetic and epidemiologic examination of personnel subjected to occupational irradiation in the Russian Federal Nuclear Center (Sarov). Report 2. Genetic and non-genetic risk factors of morbidity].

Below is given a comparative evaluation of the genetic and the epidemiological examination of the cohort comprised by VNIIEF personnel subjected chronically to gamma-neutron ionizing radiation (74 persons), as well as nonirradiated cohort (74 persons). There are obtained data on the influence of the integral genotype structure on the health of an individual in case of occupational irradiation. The epidemiological analysis revealed statistically meaningful differences between the main and the control cohorts in the following five cases: acute respiratory diseases, diseases of upper respiratory tract, brain vessel malfunctions; illnesses connected with vision organs and cardio-vascular system and traumas.

[Molecular-genetic and epidemiologic examination of personnel subjected to occupational irradiation in Russian Federal Nuclear Center (Sarov). Report 1. Genome structural damage rate and radiosensitivity].

A comparative evaluation of the cytological and dosimetric examination of the cohort comprised by VNIEF personnel subjected chronically to gamma-neutron ionizing radiation, as well as non-irradiated cohort is given. The obtained data on the influence of the occupational and on X-ray irradiation, age and smoking on the rate of structural genome damage, as well as the activity of the human repair system activity are presented. The influence of the individual heterozygosis by 9 polymorphous loci: Hp, Tf, Gc; 6-PGD, EsD, ACP, PGM1, microsatellite lici SCF1PO and F13AO1 is shown.