Colchicine in patients with heart failure and preserved left ventricular ejection fraction: rationale and design of a prospective, randomised, open-label, crossover clinical trial.

Introduction: Systemic low-grade inflammation is a fundamental pathophysiological mechanism of heart failure with preserved left ventricular ejection fraction (HFpEF). The efficacy of anti-inflammatory therapy in HFpEF is largely understudied. The aim of the study is to assess the anti-inflammatory effect of colchicine in HFpEF by looking at inflammatory biomarkers: high-sensitivity C reactive protein (hsCRP) and soluble suppression of tumorigenicity 2 (sST2).

[Diagnosis, pathogenesis and treatment of attention deficiency syndrome].

Attention deficit hyperactivity disorder is the dominant form of cognitive and behavioral dysfunctions in childhood, the disease has a chronic course and manifests in adolescents and adults in 50-80% of cases. An adequate diagnosis is the testing of parents and teachers using the Conners questionnaire in two stages, the second is mandatory after 6 months to confirm the persistence of symptoms over time. The pathogenesis is based on violations of mediation of dopamine and norepinephrine in the fronto-striate-thalamic system, responsible for the function of constant attention, caused by molecular genetic mechanisms.

Case of benralizumab-induced exacerbations of chronic spontaneous urticaria.

The role of IL-5 in chronic spontaneous urticarial (CSU) is unclear. It may be that benralizumab is an important bidirectional modifier of CSU; that is, blocking IL-5 may improve CSU in some patients, but it is possible that it may worsen CSU in others.