Publications by authors named "I B Fashina"
Introduction: Adherence to full vaccination is important in preventing childhood diseases. The aim of this study was to evaluate the level of compliance to full vaccination and identify the socio-cultural factors associated with full vaccination compliance in children.
Methodology: The socioeconomic variables associated with each of the four binary dependent variables of whether or not a child is fully vaccinated against tetanus, BCG, measles, and pentavalent were determined using logistic regression.
The modulation of macrophage phenotype from a pro-inflammatory to an anti-inflammatory state holds therapeutic potential in the treatment of inflammatory disease. We have previously shown that arginase-2 (Arg2), a mitochondrial enzyme, is a key regulator of the macrophage anti-inflammatory response. Here, we investigate the therapeutic potential of Arg2 enhancement via target site blockers (TSBs) in human macrophages.
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- GWAS identified over 200 variants linked to multiple sclerosis, but non-coding regions, particularly microRNA variants, have been under-explored despite evidence of their relevance.
- Researchers employed the largest GWAS dataset to analyze SNPs surrounding microRNAs and their effect on MS, involving nearly 116,000 participants.
- The study found 30 candidate microRNA-associated variants, highlighting specific variants that may impact microRNA stability and binding, suggesting their potential role in MS susceptibility.
Objectives: Acute appendicitis is common. This prospective study of 250 cases of acute appendicitis was performed to critically analyse the pattern of presentation, management, operative findings and treatment outcome. The effect of length and position of the appendix in relationship to acute inflammation was also determined.
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