Publications by authors named "I Aydin Candan"
Methotrexate (MTX), a widely used chemotherapeutic agent, often induces hepatotoxicity, limiting its clinical utility. Cannabidiol (CBD), derived from hemp, possesses antioxidant, anti-inflammatory, and antiapoptotic properties. This study aims to investigate CBD's protective effects against MTX-induced liver injury and elucidate the underlying mechanisms.
View Article and Find Full Text PDFArticle Synopsis
- The study focuses on the perovskite oxides XSnO3 (where X is Ca, Mg, or Sr) and investigates their structural, electronic, and optical properties using density functional theory with the FP-LAPW method.
- It reveals that XSnO3 compounds have robust crystal structures, with key parameters like lattice constants, band gap, density of states, and optical properties thoroughly analyzed.
- The findings indicate these compounds possess semi-metallic characteristics and highlight their potential for applications in electronics and optoelectronics.
Investigation of cardioprotective effect of lercanidipine on doxorubicin-induced cardiotoxicity.
Naunyn Schmiedebergs Arch Pharmacol
December 2023
Although doxorubicin (DOX) is an effective anti-neoplastic drug for many types of cancer, particularly dose-related cardiotoxicity limits the use of the drug. In this study, it was aimed to investigate the protective effect of lercanidipine (LRD) against DOX-induced cardiotoxicity. In our study, 40 Wistar albino female rats were randomly divided into 5 groups as control, DOX, LRD 0.
View Article and Find Full Text PDFArticle Synopsis
- Ramelteon (RML) is a powerful drug that targets melatonin receptors and has antioxidant and anti-inflammatory properties, and this study looks at its effects in a rat model of uveitis induced by endotoxins.
- Twenty-eight rats were divided into four groups to compare the effects of LPS alone and with RML treatment, with analyses conducted on tissue and genetic changes after inducing uveitis.
- Results indicated that RML reduced inflammation, reversed harmful changes in certain signaling pathways (HIF-1α, eNOS, VEGF), and improved the overall condition in rats treated with RML.
: The most common kidney stones are calcium stones and calcium oxalate (CaOx) stones are the most common type of calcium stones. Hyperoxaluria is an essential risk factor for the formation of these stones. Quercetin is a polyphenol with antioxidant, anti-inflammatory, and many other physiological effects.
View Article and Find Full Text PDF