[Immunomorphological characteristics and criteria for predicting gastrointestinal stromal tumors].

The study of 36 cases of gastrointestinal stromal tumors (GIST) (n = 26 of the stomach and n = 10 of the duodenum, small bowel, and rectum) indicated that among the clinical symptoms, there were prevalent abdominal pains and gastrointestinal bleeding. Local invasion and metastases were detected in 11 patients. According to the risk of aggressiveness, 1 tumor presented a very low risk; 5, a low risk; 14, a moderate risk; and 16 a high risk.

The cyclin-dependent kinase inhibitor, p27, has no correlation with the malignant potential of GIST.

Background: Tumor size and mitotic activity are characteristically associated with the malignant potential and prognosis of gastrointestinal stromal tumors (GIST). However, since neither small tumor size nor low mitotic activity can rule out malignancy, additional factors that may predict malignant behavior have been suggested.

Aim: To evaluate the correlation between the cyclin-dependent kinase inhibitor (CDI), p27kip1, expression and the malignant potential of GIST.

Skin biopsy for assessment of autonomic denervation in Parkinson's disease.

Autonomic dysfunction in Parkinson's disease (PD) is considered a late complication of the disease or an adverse effect of anti-parkinsonian medications. Morphological changes are demonstrated only by postmortem examination. The study objective was to evaluate peripheral autonomic neural involvement in PD using punch skin biopsy.

Transport of maternal immunoglobulins through the human placental barrier in normal pregnancy and during inflammation.

We studied the effect of ascending infections of the birth canal on the transport of maternal immunoglobulins (Igs) through the placental barrier in humans. The study was performed on 41 human placentas obtained from embryos (n=21) and fetuses (n=20) who had died from different causes, including those connected with ascending infections of the birth canal, and seven placentas obtained after normal delivery at term. Different morphological and immunohistochemical methods were used.

Household electromagnetic fields and breast cancer in elderly women.

The relationship between the rate of household low-frequency electromagnetic fields (EMF) and incidences of mammary tumors was studied in 1290 clinical case-records of female patients aged 60 and more over a period of 26 years, based on the materials of the Edith Wolfson Medical Center, Israel. The studied material was divided into two groups, each corresponding to a period of 13 years. Group I included patients with mammary tumors under observation from 1978 to 1990, who rarely used EMF-generating appliances.