Publications by authors named "I Asensio"
Background & Aims: Expression of P21, encoded by the gene, has been associated with fibrosis progression in steatotic liver disease (SLD); however, the underlying mechanisms remain unknown. In the present study, we investigated the function of CDKN1A in SLD.
Methods: expression levels were evaluated in different patient cohorts with SLD, fibrosis, and advanced chronic liver disease (ACLD).
Vector or reservoir species of five fish diseases listed in the Animal Health Law were identified, based on evidence generated through an extensive literature review (ELR), to support a possible updating of Regulation (EU) 2018/1882. Fish species on or in which highly polymorphic region-deleted infectious salmon anaemia virus (HPR∆ ISAV), Koi herpes virus (KHV), epizootic haematopoietic necrosis virus (EHNV), infectious haematopoietic necrosis virus (IHNV) or viral haemorrhagic septicaemia virus (VHSV) were detected, in the field or during experiments, were classified as reservoir species with different levels of certainty depending on the diagnostic tests used. Where experimental evidence indicated transmission of the pathogen from a studied species to another known susceptible species, the studied species was classified as a vector species.
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- Acetaminophen (APAP) can cause severe liver damage by triggering endoplasmic reticulum (ER) stress and the unfolded protein response (UPR) in liver cells, but the detailed mechanisms behind this are not well understood.
- In studies using specific mice models, it was found that the activation of UPR and the JNK1/2 pathway were significant in APAP-induced liver toxicity, and that the XBP1 gene played a crucial role in this process.
- Blocking or reducing the activity of XBP1 in liver cells helped reduce liver injury by promoting autophagy and lowering the expression of CYP2E1, indicating potential new treatments for serious liver damage.
Article Synopsis
- The study investigates the effects of combining intermediate alcohol consumption with a Western diet to create a mouse model (DUAL) that simulates both alcohol-associated and metabolic fatty liver diseases.
- Mice on the DUAL diet showed significant weight gain, liver damage, and signs of metabolic distress, including increased fat cell size, high cholesterol, and high blood sugar levels.
- The findings suggest that this DUAL model closely resembles human advanced steatohepatitis, making it a useful preclinical tool for finding new treatments.
Purpose: To evaluate the impact of the hormonal treatment sequencing including abiraterone acetate plus prednisone (AAP) and enzalutamide (ENZ) in mCRPC, and determine which sequence provides more benefits for patients.
Methods: Studies published in English between 1 January 2013 and 30 September 2017 were identified in PubMed and EMBASE electronic databases. Studies assessing the efficacy of treatment sequences, based on AAP and ENZ, in mCRPC patients, were eligible for analysis.