Publications by authors named "I Artamonova"
Background: Illicitly manufactured fentanyl (IMF) increases overdose mortality, but its role in infectious disease transmission is unknown. We examined whether IMF use predicts hepatitis C virus (HCV) and human immunodeficiency virus (HIV) incidence among a cohort of people who inject drugs (PWID) in San Diego, California and Tijuana, Mexico.
Methods: PWID were recruited during 2020-2022, undergoing semi-annual interviewer-administered surveys and HIV and HCV serological rapid tests through 2024.
Article Synopsis
- A patient was found to have a germline heterozygous truncating variant in a specific gene, leading to neurodevelopmental disorder with spastic diplegia and visual defects syndrome (NEDSDV).
- This case revealed a new clinical feature of severe pediatric-onset osteoporosis and multiple fractures linked to the genetic variant.
- Laboratory analysis using stem cells showed changes in mRNA and β-catenin protein levels, indicating a functional impact of the identified genetic variant.
Cracking the antigenic code of mycobacteria: CFP-10/ESAT-6 tuberculosis skin test and misleading results.
J Clin Tuberc Other Mycobact Dis
August 2024
There are different tuberculosis diagnostic tools available that detect an antigen-specific immune response. The present study aims to evaluate the potential of cross-reactive responses of a CFP-10 and ESAT-6 antigen-based TB test using bioinformatics tools. The study found that the presence of the sequences coding for the CFP-10 and ESAT-6 antigens in mycobacterial genomes is not associated with their pathogenicity, and not even consistent within a single species among its strains, which can lead to either false positive or false negative test results.
View Article and Find Full Text PDFBackground: We examined HIV prevalence and transmission dynamics among people who inject drugs in the U.S./Mexico border region during the COVID-19 pandemic.
View Article and Find Full Text PDFArticle Synopsis
- Long-acting injectable HIV pre-exposure prophylaxis (LAI-PrEP) could address challenges in HIV prevention for people who inject drugs (PWID) in the San Diego-Tijuana area, though awareness and interest in LAI-PrEP remain low among this group.
- A study with 562 HIV-negative PWID revealed only 18% were aware of general PrEP, and factors like homelessness, fentanyl injection, and transactional sex were linked to this low awareness.
- Interest was primarily in oral PrEP (44%), with LAI-PrEP interest at 25%, showing that those facing severe drug-related issues may prefer LAI-PrEP due to difficulties adhering to oral medication.