CIC-Related Neurodevelopmental Disorder: A Review of the Literature and an Expansion of Genotype and Phenotype.

Background: Genetic testing for neurodevelopmental disorders is now considered the standard of care for unexplained epilepsy as well as autism spectrum disorders, intellectual disability, and developmental delays with as many as 50% of individuals identified as having an underlying genetic etiology. Capicua () is a transcriptional repressor and is widely expressed among human brain tissue. Patients in the literature with pathogenic variants in present with a broad spectrum of phenotypic abnormalities.

LD-transpeptidation is crucial for fitness and polar growth in Agrobacterium tumefaciens.

Peptidoglycan (PG), a mesh-like structure which is the primary component of the bacterial cell wall, is crucial to maintain cell integrity and shape. While most bacteria rely on penicillin binding proteins (PBPs) for crosslinking, some species also employ LD-transpeptidases (LDTs). Unlike PBPs, the essentiality and biological functions of LDTs remain largely unclear.

Recycling the rain: Exploring forest management practices in a western Mediterranean watershed to recouple the atmospheric and terrestrial water cycle.

Current knowledge of the role that forests play in recycling rainwater has led to the proposal of forest management practices to mitigate desertification in the western Mediterranean basin. Building upon this hypothesis, we present the Mijares watershed in eastern Spain as a detailed case study. We then perform a scientific literature review in the context of the western Mediterranean basin to identify the physical and biophysical uncertainties associated with forest management practices that aim to strengthen the atmospheric and terrestrial components of the water cycle.

Innovative Approach to Accelerate Wound Healing: Synthesis and Validation of Enzymatically Cross-Linked COL-rGO Biocomposite Hydrogels.

In this study, an innovative conductive hybrid biomaterial was synthetized using collagen (COL) and reduced graphene oxide (rGO) in order for it to be used as a wound dressing. The hydrogels were plasticized with glycerol and enzymatically cross-linked with horseradish peroxidase (HRP). A successful interaction among the components was demonstrated by FTIR, XRD, and XPS.

Coastal current convergence structures in the Bay of Biscay from optimized high-frequency radar and satellite data.

The southeastern Bay of Biscay has been described as a "dead end" for floating marine litter, often accumulating along small-scale linear streaks. Coastal Current Convergence Structures (CCS), often associated with vertical motions at river plume edges, estuarine fronts, or other physical processes, can be at the origin of the accumulation. Understanding the formation of CCS and their role in the transport of marine litter is essential to better quantify and to help mitigate marine litter pollution.