Multivitamins After Myocardial Infarction in Patients With Diabetes: A Randomized Clinical Trial.

Importance: In 2013, the Trial to Assess Chelation Therapy (TACT) reported that in 1708 patients with stable coronary disease and prior myocardial infarction (MI), oral multivitamins and multiminerals (OMVMs), in a factorial design with edetate disodium (EDTA) chelation therapy, did not reduce cardiovascular events relative to placebo OMVMs, but active EDTA combined with active OMVMs was superior to placebo OMVM/placebo EDTA.

Objective: To compare OMVM vs placebo in terms of efficacy for reducing major adverse cardiovascular events in patients with diabetes and prior MI.

Design, Setting, And Participants: The TACT2 randomized, multicenter double-masked 2 × 2 factorial clinical trial took place across 88 sites in the US and Canada.

spiders (Trechaleidae) from southern Mexico: DNA barcoding, venomics, and biological effect.

Background: Members of the genus Simon, 1891 are categorized as wandering spiders and are part of the family Trechaleidae. The genomics and proteomics of spiders from North America remain uncharacterized. The present study explores for the first time molecular data from the endemic species Medina, 2006, and also presents new data for (Keyserling, 1878), both collected in southern Mexico.

A consensus recombinant elapid long-chain α-neurotoxin and how protein folding matters for antibody recognition and neutralization of elapid venoms.

Antivenoms are essential in the treatment of the neurotoxicity caused by elapid snakebites. However, there are elapid neurotoxins, e.g.

AMPK inhibits voltage-gated calcium channel-current in rat chromaffin cells.

Metabolic changes are critical in the regulation of Ca influx in central and peripheral neuroendocrine cells. To study the regulation of L-type Ca channels by AMPK we used biochemical reagents and ATP/glucose-concentration manipulations in rat chromaffin cells. AICAR and Compound-C, at low concentration, significantly induce changes in L-type Ca channel-current amplitude and voltage dependence.