Publications by authors named "I Alexiev"
The increased life expectancy of PLHIV (People Living with HIV) and the successful highly combined antiretroviral therapy (cART) poses new clinical challenges regarding aging and its co-morbid condition. It is commonly believed that HIV infection "accelerates" aging. Human immunodeficiency virus type 1 (HIV-1) infection is characterized by inflammation and immune activation that persists despite cART, and that may contribute to the development of co-morbid conditions.
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- * Seasonal respiratory viruses were detected using multiplex PCR and next-generation sequencing, highlighting the highest coinfection rate (15%) in patients 16 years and younger.
- * Whole-genome sequencing revealed various genetic groups among the detected viruses and multiple amino acid substitutions, emphasizing the need for understanding viral interactions for effective treatment and prevention strategies.
Article Synopsis
- Respiratory syncytial virus (RSV) is a significant cause of respiratory infections, and a study in Bulgaria aimed to assess its prevalence and genetic diversity alongside other viruses from 2020 to 2023.
- Out of 3,047 patients with respiratory issues, 59.5% tested positive for viral pathogens, with RSV being the second most common at 10.9%, especially affecting children under 5 years old.
- The research found a marked increase in RSV cases in the 2022-2023 season, with specific genetic strains identified, indicating a resurgence post-COVID-19 restrictions.
The COVID-19 pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has brought about significant challenges worldwide. In this study, we present a comprehensive analysis of the genomic epidemiology and lineage dynamics of SARS-CoV-2 in Bulgaria over a three-year period. Through extensive genomic sequencing and data analysis, we investigated the evolution of the virus, the emergence of variants of concern (VOCs), and their impact on the country's pandemic trajectory.
View Article and Find Full Text PDFThe first recombinant SARS-CoV-2 variants were identified in 2022, causing public health concerns. The importance of recombinant variants has increased especially since the WHO designated the recombinant variant XBB and its lineages as subvariants that require monitoring on 20 November 2022. In this study, we provide the first insights into the new SARS-CoV-2 variant named XAN, a recombinant composed of Omicron sub-lineages BA.
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