Synthetic models related to methoxalen and menthofuran-cytochrome P450 (CYP) 2A6 interactions. benzofuran and coumarin derivatives as potent and selective inhibitors of CYP2A6.

Human microsomal cytochrome P450 (CYP) 2A6 contributes extensively to nicotine detoxication but also activates tobacco-specific procarcinogens to mutagenic products. We prepared a series of benzofuran and coumarin derivatives that have inhibitory effects on the activity of human CYP2A6. The reported compounds methoxalen and menthofuran had potent inhibitory effects on the activity of CYP2A6 with IC50 values of 0.

FID detection of EPR and ENDOR spectra at high microwave frequencies.

High-frequency pulsed EPR spectroscopy allows FID detection of EPR spectra owing to the short dead time that can be achieved. This FID detection is particularly attractive for EPR and ENDOR spectroscopy of paramagnetic species that exhibit inhomogeneously broadened EPR lines and short dephasing times. Experiments are reported for the metalloprotein azurin at 275 GHz.

Multifrequency EPR analysis of the positive polaron in I2-doped poly(3-hexylthiophene) and in poly[2-methoxy-5-(3,7-dimethyloctyloxy)]-1,4-phenylenevinylene.

The W-band continuous-wave electron paramagnetic resonance (EPR) analysis of chemically induced polarons in drop-cast and spin-coated polyphenylenevinylene-type and polythiophene-type polymer films reveals rhombic g tensors in both cases. The dependence of the W-band EPR signals on the orientation of the spin-coated films with respect to the magnetic field indicates a high degree of backbone alignment with the substrate and allows a partial assignment of the g tensor orientation. The derived molecular orientations of the polymer chains in the spin-coated films show clear differences between the two types of polymers.