Publications by authors named "I Akashi"
Article Synopsis
- Glomerular lipidosis is a rare kidney condition characterized by lipid buildup in the glomeruli and can be associated with macrophage activation syndrome (MAS).
- A 42-year-old patient who underwent kidney transplantation developed proteinuria and high serum triglycerides, leading to a biopsy showing CD68 foam cells and CD3 T-cells, suggesting histiocytic involvement.
- The patient was diagnosed with renal-limited MAS and treated with lipid-lowering therapy, successfully normalizing triglyceride levels, while the effectiveness of immunosuppressants remained unchanged.
Article Synopsis
- Early recovery in septic shock patients improves their overall prognosis, and the study explored whether Continuous Renal Replacement Therapy (CRRT) using polymyxin B (PMX-DHP) can stabilize their hemodynamics.
- 66 septic shock patients underwent PMX-DHP, with some receiving additional continuous hemodiafiltration (CHDF), and measurements of inflammatory cytokines (IL-6, IL-1ra, PAI-1) were taken before and after treatment.
- Results showed that PMX-DHP significantly increased Mean Arterial Pressure (MAP) and reduced cytokine levels, indicating that CRRT may be an effective strategy to improve outcomes in septic shock by modulating cytokine activity.
Kidney biopsy is commonly used to diagnose kidney transplant dysfunction after transplantation. Therefore, the development of minimally invasive and quantitative methods to evaluate kidney function in transplant recipients is necessary. Here, we used capillary electrophoresis-mass spectrometry to analyze the biofluids collected from transplant recipients with impaired (Group I, n = 31) and stable (Group S, n = 19) kidney function and from donors (Group D, n = 9).
View Article and Find Full Text PDFRecently, steroid reduction/withdrawal regimens have been attempted to minimize the side effects of steroids in renal transplantation. However, some recipients have experienced an increase/resumption of steroid administrations and acute graft rejection (AR). Therefore, we investigated the relationship between the individual lymphocyte sensitivity to steroids and the clinical outcome after steroid reduction/withdrawal.
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