Publications by authors named "I Ahmed Imam"
Phosphatases are enzymes that catalyze the hydrolysis of phosphate esters. They play critical roles in diverse biological processes such as extracellular nucleotide homeostasis, transport of molecules across membranes, intracellular signaling pathways, or vertebrate mineralization. Among them, tissue-nonspecific alkaline phosphatase (TNAP) is today increasingly studied, due to its ubiquitous expression and its ability to dephosphorylate a very broad range of substrates and participate in several different biological functions.
View Article and Find Full Text PDFBackground: Total neoadjuvant treatment (TNT) for locally advanced rectal cancer (LARC) increases pathologic complete response (pCR) rate and reduces the risk of systemic recurrences over chemoradiotherapy (CRT) in randomised trials, e.g., the RAPIDO trial.
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- Acquired resistance to cancer treatments, particularly for EGFR mutations, leads to cancer recurrence and limits treatment effectiveness, especially with drugs like osimertinib.
- The study employs molecular dynamics simulations to analyze two specific EGFR mutants (L858R/L718Q and L858R/L792H) that resist osimertinib, compared to the wild-type EGFR.
- Findings indicate that these secondary mutations create additional hydrogen bonds, reducing the binding target exposure for osimertinib and altering the binding affinity, which may inform future drug development strategies.
was recently added to the list of threatening pathogens affecting more than 300 plant hosts. Hemipteran hoppers that feed on xylem have been documented as potential transmitters. Hemipteran hoppers, known vectors for plant pathogens via xylem feeding, pose significant risks to agriculture.
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- A study in Abeokuta, Nigeria, found that a significant 73.2% of women in intimate relationships experienced some form of intimate partner violence (IPV), affecting their physical and mental health.
- The most common types of IPV reported were psychological/emotional violence (66.1%) and physical violence (47.5%), with examples including insults, public embarrassment, and slapping.
- The study highlights the urgent need for government action to raise awareness and invest in women's empowerment to combat the high rates of IPV.