Publications by authors named "I Accoceberry"
Article Synopsis
- The study focuses on evaluating the effectiveness of serum galactomannan (GM) testing for diagnosing invasive aspergillosis (IA) in children with cancer, as previous research mainly involves adults.
- Conducted at the University Hospital of Bordeaux, the study observed a low prevalence of IA among high-risk pediatric patients and found that the GM test had poor sensitivity and positive predictive value (PPV), especially when patients were on antifungal prophylaxis.
- The authors suggest that rather than routine screening, testing should be focused on the highest-risk patients, and combining GM with other diagnostic methods like Aspergillus PCR might improve accuracy.
We report a severe case of kerion Celsi of the scalp in a previously healthy 13-year-old girl due to Trichophyton quinckeanum, an emerging dermatophyte species in Europe. The species was definitely identified by DNA sequencing and the patient was successfully treated by oral terbinafine for 6 weeks. Kerion Celsi is a severe inflammatory form of tinea capitis, which is characterised by a purulent discharge and alopecia [1].
View Article and Find Full Text PDFObjectives: Caspofungin is an echinocandin antifungal agent that inhibits synthesis of glucan required for the fungal cell wall. Resistance is mediated by mutation of Fks1 glucan synthase, among which S645P is the most common resistance-associated polymorphism. Rapamycin is a macrolide that inhibits the mechanistic target of rapamycin (mTOR) protein kinase activity.
View Article and Find Full Text PDFCryptococcosis is the third most common cause of invasive fungal infection in solid organ transplant recipients and cryptococcal meningitis (CM) its main clinical presentation. CM outcomes, as well as its clinical features and radiological characteristics, have not yet been considered on a large scale in the context of kidney transplantation (KT). We performed a nationwide retrospective study of adult patients diagnosed with cryptococcosis after KT between 2002 and 2020 across 30 clinical centers in France.
View Article and Find Full Text PDFPurpose: In the era of effective prophylaxis, the objective of this study was to describe pneumocystis pneumonia (PCP) patients' profile and evaluate the consistency of clinical situations encountered with the recommended indications for prophylaxis.
Methods: This was a single-centre, retrospective study. All adults (> 18 years) with a definitive diagnosis of PCP were included.